Our Technology

Cell Culture

Cell Culture Compatible

OBI coined the term “Cell Culture Compatible” to describe proprietary delivery technologies designed to enable ingredients and finished formulations to be evaluated directly in human skin-cell culture models, including keratinocytes, melanocytes, and fibroblasts.

These delivery systems are designed for low cytotoxicity in in vitro test systems and utilize carefully controlled particle-size characteristics to support ingredient dispersion, formulation compatibility, and performance. OBI’s proprietary bio-emulsifiers and controlled-release technologies are key components of these systems.

Inspired by naturally occurring lipid structures, these technologies are designed to improve the incorporation and distribution of selected ingredients within cosmetic formulations. The Cell Culture Compatible platform provides a practical research tool for screening and optimizing ingredients and finished formulations for formulation performance, and skin-relevant cosmetic applications.

HyperVitamin Therapy Delivery

By attaching proprietary Omega-36 lipid components to selected vitamins and bioactive ingredients, OBI creates specialized ester-based derivatives designed to improve ingredient compatibility, stability, and incorporation within cosmetic formulations. This Bio-Ester technology supports the use of higher concentrations of selected vitamins while helping optimize skin feel, tolerability, and overall formulation performance.

SERT: Selective Enzyme Release Technology®

Selective Enzyme Release Technology (SERT) is designed to improve ingredient compatibility and skin tolerability through specially engineered molecules that can be modified by naturally occurring enzymes present at the skin surface.

OBI utilizes biosurfactants such as sucrose esters, polyglyceryl lactylates, phosphatidic acids, and ascorbyl laurate as alternatives to conventional surfactant systems. These materials are designed from familiar lipid-, sugar-, amino acid-, and vitamin-related building blocks and are selected for their favorable compatibility with skin-focused formulations.

Selected cosmetic ingredients, including ascorbic acid, tocopherol, gallic acid, lactic acid, and oligopeptides, may be linked to fatty acids or glycerides to create specialized functional derivatives with improved formulation stability, dispersibility, and compatibility. Through OBI’s proprietary Bio-Emulsifier and Omega-36 Bio-Ester technologies, these materials can be designed to self-assemble into finely dispersed systems that support uniform ingredient distribution and optimized topical formulation performance.

OBI’s development philosophy emphasizes the use of well-characterized, skin-compatible molecular building blocks to create advanced functional skincare ingredients with an emphasis on stability, tolerability, formulation compatibility, and cosmetic performance.

BioEmulsifiers / Omega 36 Bioesters

OBI was founded on the development of advanced, skin-compatible delivery and formulation systems for topical cosmetic ingredients. By reducing reliance on conventional surfactants, OBI utilizes proprietary Bio-Emulsifier and Omega-36 Bio-Ester technologies to create emulsions and anhydrous formulation systems designed to support ingredient stability, distribution, skin feel, and overall product performance.

Our technology platform includes NOP-compliant organic emulsifier options and naturally derived bio-emulsifiers designed for use in cell-compatible emulsions, liposomal systems, microemulsions, and nanoemulsions. These systems are engineered with an emphasis on low cytotoxicity in appropriate in vitro models, formulation compatibility, and the efficient incorporation of selected cosmetic ingredients.

OBI integrates these delivery technologies with its proprietary Cell Culture Compatible screening platform to evaluate ingredients and finished formulations during the development process. This approach allows formulations to be screened and refined for parameters such as cell compatibility, ingredient performance, stability, and formulation behavior prior to more advanced product testing.

Nanoemulsion and microemulsion systems may be further optimized using selected biosurfactants derived from fatty acids, sugars, amino-acid-related materials, and other well-characterized components, together with advanced high-pressure processing technologies.

Through specialized processing capabilities, rigorous ingredient qualification, and a portfolio of proprietary and patent-protected technologies, OBI provides advanced formulation platforms designed to support the development of high-performance functional skincare products.

Variable Dosage Pulsed Titration

Pulsed Titration is a structured skincare approach in which concentrated cosmetic formulations are used for short intervals, followed by a rest period with a simple moisturizer or supportive skincare product.

This alternating-use approach is designed to help optimize cosmetic performance while supporting skin comfort and minimizing the potential for irritation associated with continuous use of more intensive formulations.

Product strength and frequency of use may be adjusted based on individual skin characteristics, age, tolerance, and personal preference. Pulsed Titration provides a flexible method for incorporating advanced functional skincare products into a routine while maintaining a focus on skin appearance, texture, and overall condition.

Advanced Topical Ingredient Technology

Aqueous Based

OBI’s innovative aqueous gel systems are designed to support the incorporation and performance of advanced peptides and lipopeptides with a focus on skin compatibility and formulation stability. Using naturally derived lipopeptide biosurfactants, these systems can incorporate ingredients such as magnesium ascorbyl phosphate, retinol derivatives, and tocopherols within suspended microspheres without the need for additional conventional surfactants.

This approach is designed to help maintain ingredient stability, uniform distribution, and overall formulation performance while supporting skin tolerability. OBI evaluates these systems using in vitro human skin-cell models and, where applicable, appropriate clinical or consumer testing to assess cosmetic performance, skin compatibility, and visible skin benefits.

 

Standard Emulsions

OBI has developed a series of advanced oil-in-water emulsions designed to support skin moisturization, comfort, and overall cosmetic performance. These formulations are engineered with minimal free surfactant content to help reduce irritation potential and improve skin compatibility.

A range of viscosities and advanced formulation formats—including nanoemulsions and suspended microspheres—allows precise control over rheology, texture, ingredient distribution, and product application characteristics. These systems can be tailored to support formulation stability, sensory properties, and the performance of selected cosmetic ingredients.

Nano-Emulsions

These oil-in-water systems, with particle sizes typically in the 100–200 nm range, are designed to improve the dispersion and incorporation of lipophilic cosmetic ingredients through their high surface-area-to-volume ratio. They may be incorporated into aqueous gels or conventional emulsions to support solubilization, formulation uniformity, and the overall performance of hydrophobic ingredients.

Their small particle size also allows for precise control of texture, stability, and ingredient distribution within advanced topical formulations.

 

Bio-Emulsions

Structurally similar to nanoemulsions, these systems use exclusively natural emulsifiers such as lecithin and fatty acids. They integrate seamlessly into high-performance or certified oStructurally similar to nanoemulsions, these systems utilize naturally derived emulsifiers such as lecithin and selected fatty acids to create finely dispersed oil-in-water structures. They are designed to support the incorporation, solubilization, and uniform distribution of lipophilic functional ingredients within advanced cosmetic formulations.

Depending on ingredient composition and qualification, these systems may be incorporated into high-performance skincare products or formulations developed to meet applicable organic certification standards. Their flexible composition supports formulation stability, ingredient compatibility, and optimized sensory and application characteristics.rganic formulations, depending on the lipophilic bioactive agents included.

Anhydrous

OBI specializes in the development of advanced surfactant-free formulation systems. Hydrophobic triglyceride bases are used to incorporate selected lipophilic functional ingredients together with naturally derived components such as certified organic oleic acid.

These systems are designed to support ingredient solubilization, formulation uniformity, and skin compatibility while accommodating higher concentrations of selected cosmetic ingredients. The result is a flexible anhydrous platform engineered for low irritation potential, controlled application characteristics, and high-performance topical formulations.

Exclusive Performance Ingredients

Fatty Acids, Glycerides, and BioEsters Of:

  • Safflower
  • Sunflower
  • Olive
  • Kukui
  • Macadamia
  • Argan
  • Seabuckthorn
  • Primrose
  • Borage

Retinoid Derivatives

  • Glyceryl Diretinoate (GDR)
  • Retinyl Safflowerate (Retinyl Linoleate)

Oligopeptides and Lipo-Oligopeptides

Mono-Linoleoyl Phosphatidyl Choline (>75%)

Lysophosphatidic Acid (>75%)

Ascorbic Acid Omega 3 and Omega 6 Esters Of:

  • Safflower
  • Sunflower
  • Olive
  • Kukui
  • Macadamia
  • Argan
  • Seabuckthorn
  • Primrose
  • Borage

Enhanced Vitamin E Esters

  • Tocopheryl Ferulate
  • Tocopheryl Safflowerate

Polyhydroxy Benzoate Esters with Enhanced Solubility and Activity

  • Caffeinate
  • Gallate
  • Gentisate Glyceride Esters

MSH Inhibitors

Thiols, Esters, and Amides

  • Safflower Cysteinate
  • Safflower Cysteinyl Glutathione
  • Ascorbyl Cysteinate